Earlier in the play, Lady Macbeth is presented as an indifferent, uncaring character with qualities of a “fiend-like” queen. When Macbeth murders King Duncan, she does not comfort her horrified husband who can no longer look at his hands. Rather, she insults his manhood: “infirm of purpose” and describes him as “white” hearted and cowardly. This is a character who appears not to care about the consequences of her actions, and mocks Macbeth for feeling any regret at all. There is a strong sense of apathy about her character as she chooses to focus on framing the servants instead of expressing remorse: “go”, “get”, “carry”. The chain of imperatives in her language highlight her almost mechanical lack of regret as she works to destroy any evidence of their involvement. A Jacobean audience would be particularly shocked at this presentation because regicide was considered the most blasphemous, horrific act to commit. To remain indifferent to this treacherous crime would be considered a very fiendish quality. However, a contrasting interpretation suggests that Lady Macbeth does express a non-fiendish, sensitive side. During the same scene as Duncan’s murder, she reveals had Duncan “not resembled my father… I had done’t”. This suggests that she does possess a moral side to her character which prevents her from killing someone similar to her father. Furthermore, there is a suggestion that to frame the two servants, she needed alcohol to “make me bold”. This is not something an innately fiendish or cruel person would need to do. Therefore, it is more plausible that the callous side to Lady Macbeth we are presented with in this scene - “a little water clears us of” guilt- is a façade. A façade she uses to cover up the immense distress she feels, and one that may be a result of ruthless pragmatism, rather than wickedness.
Lady Macbeth is later presented as more devilish when she rejects her humanity and femininity. This is an unnatural desire which connects her with the “murdering ministers” and isolates her from God: “tend on mortal thoughts”; “unsex me”; “take my milk for gall”. She appears to shun human nature itself in order to commit this crime. Religion was a very prevalent part of Jacobean society. To have utter disregard for God’s will was considered sacrilegious, and a fiendish desire. No longer does wish she wish to be human: “fill me… of direst cruelty”. The superlative “direst” connoting an extreme level of detachment from humanity and God. However, a much stronger interpretation suggests that Lady Macbeth does this sacrificially in order to help her husband achieve kingship. The character is presented as wishful and ambitious for her husband’s benefit: she wants him to be “crowned withall!” and fears that he is “too full of the milk of human kindness” to do so. She states that he should “leave all the rest to me” which suggests she is willing to do everything necessary to help her husband. This is a very loving characteristic. Perhaps she is willing to lose her humanity in order to help Macbeth with his rise to the throne. Whilst she does appear to act diabolically by rejecting her humanity, it is clear that Lady Macbeth’s motives for doing so are very human, and not “fiend-like” in nature.
Lady Macbeth is presented as most “fiend-like” when Shakespeare establishes a duplicity about her character. When in the courtyard of her castle, she is described as “our honoured hostess!” with “fair and noble” qualities by King Duncan. She effectively portrays herself as a an “innocent flower”. This is juxtaposed with the infamous “unsex me” scene when she is presented as a very wicked character who is out of sync with the sacredness of life. In that scene, she would have “dashed the brains out” of her own child and ominously states that Duncan “never shall sun that morrow see!” Through the juxtaposition of the “sweet” and “serpent” like qualities of Lady Macbeth, Shakespeare suggests this is a fiendish character capable of great deceit: “beguile the time, look like the time”. However, a much greater interpretation suggests that this duplicity is not enduring- it dissipates as the play progresses. Later in the play, her guilt over killing Duncan is presented as uncontrollable and impossible to conceal She begins to walk and confess her sins during her sleep: she “write upon’t” a piece of paper, and exclaims that “the old man… had so much blood”. She appears unable to control her abhorrence for her actions: “out, damned spot! Out!” Lady Macbeth is no longer a character who can plot regicide, and then be a “noble” hostess to that very king. This fiendish duplicity is absent from her character later, and suggests that Lady Macbeth is not completely demonic in nature.
Lady Macbeth is often a character who behaves in a “fiend-like” manner. She callously plots regicide, expresses no regret over Duncan’s murder, rejects her own humanity and is presented as a very deceptive character. All of these are the qualities of a wicked demonic character. However, a much deeper reading shows that there are often very human motives for these actions. Perhaps her lack of remorse over Duncan’s murder is a method of coping with the distress, or the rejection of her humanity was to help her husband achieve kingship. It is clear that Lady Macbeth is a character capable of both wicked and human qualities, but for Malcolm to describe her as an entirely “fiend-like queen” is not apt description for this complex character. 
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